IT2033 BIO INFORMATICS Syllabus

IT2033  BIO INFORMATICS  Syllabus

IT2033                                  BIO INFORMATICS                       L  T  P  C
                                                                                      3  0  0  3

UNIT I                               9
Introduction  to  molecular  biology  –  the  genetic  material  –  gene  structure  –  protein
structure – chemical bonds – molecular biology tools – genomic information content

UNIT II                               9
Data searches – simple alignments – gaps – scoring matrices – dynamic programming –
global and local alignments – database searches – multiple sequence alignments
Patterns  for  substitutions  –  estimating  substitution  numbers  –  evolutionary  rates  –
molecular clocks – evolution in organelles

UNIT III                             9
Phylogenetics – history and advantages – phylogenetic trees – distance matrix methods
–  maximum  likelihood  approaches  –  multiple  sequence  alignments  –  Parsimony  –
ancestral  sequences  –  strategies  for  faster  searches  –  consensus  trees  –  tree
confidence – comparison of phylogenetic methods – molecular phylogenies

UNIT IV                             9
Genomics  –  prokaryotic  genomes:  prokaryotic  gene  structure  –  GC  content  -  gene
density – eukaryotic genomes: gene  structure – open  reading  frames – GC  content –
gene expression – transposition – repeated elements – gene density



UNIT V                             9
Amino acids – polypeptide composition – secondary structure –  tertiary and quaternary
structure  –  algorithms  for modeling  protein  folding  –  structure  prediction  –  predicting
RNA secondary structures
Proteomics  –  protein  classification  –  experimental  techniques  –  inhibitors  and  drug
design  –  ligand  screening  –  NMR  structures  –  empirical  methods  and  prediction
techniques – post-translational modification prediction

                TOTAL:  45 PERIODS
TEXT BOOK:
1.  D. E. Krane and M. L. Raymer,  “Fundamental concepts of Bioinformatics”, Pearson
Education, 2003.

REFERENCES:
1.  Arthur M.  Lesk,  “Introduction  to Bioinformatics”, Second Edition, Oxford University
Press, 2005.
2.  T.  K. Attwood, D.  J.  Parry-Smith,  and  S.  Phukan,  “Introduction  to Bioinformatics”,
Pearson Education, 1999.
3.  Vittal R. Srinivas,  “Bioinformatics – A Modern Approach”, Prentice-Hall of  India Pvt.
Ltd., 2005.